Resource Type

Journal Article 100

Conference Videos 2

Year

2023 13

2022 12

2021 11

2020 4

2019 4

2018 5

2017 4

2016 5

2015 2

2014 2

2013 3

2012 7

2011 1

2010 4

2009 11

2008 2

2007 6

1999 1

open ︾

Keywords

heterogeneity 4

tumor 4

angiogenesis 3

metastasis 3

Colorectal cancer 2

Exosomes 2

Heterogeneity 2

PD-L1 2

Point of care 2

Tumor 2

cancer therapy 2

carcinoma 2

immune checkpoint inhibitor 2

immunotherapy 2

lung cancer 2

molecular classification 2

tumor immunotherapy 2

tumor microenvironment 2

4-1BB ligand 1

open ︾

Search scope:

排序： Display mode:

Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

HTML PDF Collect

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 551-561 doi: 10.1007/s11684-020-0760-2

Abstract: Glioma is the most common lethal tumor of the human brain.distinguish the normal brain from other tissues, e.g., the composition of the microenvironment around the tumorSeveral studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment.In this review, we introduce the different mechanisms involved in glioma progression, including tumorheterogeneity, the tumor microenvironment and drug resistance, and their pre-clinical implements in

Keywords： glioma     evolution mechanism     strategies     tumor heterogeneity     secondary glioma    

HTML PDF Collect

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract: This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations

Keywords： chronic obstructive pulmonary disease     heterogeneity     phenotype     genotype     prediction    

HTML PDF Collect

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumorThe signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varying

Keywords： moonlighting function     tumor metabolism     epigenetics    

HTML PDF Collect

Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 426-439 doi: 10.1007/s11684-018-0663-7

Abstract:

Tumor microenvironment (TME) is comprised of cellular and non-cellular components that exist withinand around the tumor mass.Given the importance of TME in tumor progression and therapy resistance, strategies that remodel TME

Keywords： tumor microenvironment     therapy response     treatment resistance    

HTML PDF Collect

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: However, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cellSingle-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected fromM2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumorImmunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansionThus, our findings provided a clinical rationale for targeting tumor microenvironments and reprogramming

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment     tumor-associated macrophage     metabolism    

HTML PDF Collect

Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 67-78 doi: 10.1007/s11684-012-0176-8

Abstract: Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor, which fosters tumor cells to become more aggressive and metastatic.on the pioneering work on tumor blood vessels by several other researchers.roles in tumor neovascularization, growth, and metastasis.Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor

Keywords： angiogenesis     vasculogenesis     neovascularization     tumor     vasculature     normalization     traditional Chinese medicine    

HTML PDF Collect

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract: genetically modifying NK cell lines by increasing their expression of cytokines and engineering chimeric tumorIn this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell     natural killer cell line     tumor immunotherapy     genetic modification    

HTML PDF Collect

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety

Keywords： vaccine     nanoparticle     tumor     immunotherapy     microenvironment    

HTML PDF Collect

Computational modeling of fracture in concrete: A review

Luthfi Muhammad Mauludin, Chahmi Oucif

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 3,   Pages 586-598 doi: 10.1007/s11709-020-0573-z

Abstract: As heterogeneity of concrete material is major concern in micromechanical-based concrete modeling, one

Keywords： concrete fracture     macroscopic     micromechanical     heterogeneity    

HTML PDF Collect

carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4,   Pages 536-545 doi: 10.1007/s11705-021-2067-5

Abstract: recurrence after tumor resection, both free BCNU and BCNU- poly (lactic-co-glycolic acid) (the ratioThe hydrogel was injected into the resection cavity of a glioblastoma tumor immediately after tumor removalFree drugs were released instantly to kill the residual tumor cells, while drugs in nanoparticles werecontinuously released to achieve a continuous and effective inhibition of the residual tumor cells forThese combined actions effectively restricted tumor growth in rats.

Keywords： BCNU     glioblastoma recurrence     tumor resection     nanoparticles     hydrogel    

HTML PDF Collect

Analysis of stress and failure in rock specimens with closed and open flaws on the surface

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1222-1237 doi: 10.1007/s11709-021-0773-1

Abstract: The influence of closed and open surface flaws on the stress distribution and failure in rock specimens is investigated. Heterogeneous finite element models are developed to simulate the compression tests on flawed rock specimens. The simulated specimens include those with closed flaws and those with open flaws on the surface. Systematic analyses are conducted to investigate the influences of the flaw inclination, friction coefficient and the confining stress on failure behavior. Numerical results show significant differences in the stress, displacement, and failure behavior of the closed and open flaws when they are subjected to pure compression; however, their behaviors under shear and tensile loads are similar. According to the results, when compression is the dominant mode of stress applied to the flaw surface, an open flaw may play a destressing role in the rock and relocate the stress concentration and failure zones. The presented results in this article suggest that failure at the rock surface may be managed in a favorable manner by fabricating open flaws on the rock surface. The insights gained from this research can be helpful in managing failure at the boundaries of rock structures.

Keywords： surface flaw     heterogeneity     circular hole     numerical modeling     relative displacement    

HTML PDF Collect

Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: Tumor growth is an angiogenesis-dependent process and accompanied by the formation of hypoxic areas.Tumstatin is a tumor-specific angiogenesis inhibitor that suppresses the proliferation and induces theTreatment with VNP-Tum5 effectively suppressed tumor growth and prolonged survival in the mouse modelThis study is the first to use tumstatin-transformed VNP20009 as a tumor-targeted system for treatmentof melanoma by combining anti-tumor and anti-angiogenic effects.

Keywords： Salmonella VNP20009     tumstatin     B16F10     melanoma     apoptosis     angiogenesis    

HTML PDF Collect

A multiscale material model for heterogeneous liquid droplets in solid soft composites

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1292-1299 doi: 10.1007/s11709-021-0771-3

Abstract: Liquid droplets in solid soft composites have been attracting increasing attention in biological applications. In contrary with conventional composites, which are made of solid elastic inclusions, available material models for composites including liquid droplets are for highly idealized configurations and do not include all material real parameters. They are also all deterministic and do not address the uncertainties arising from droplet radius, volume fraction, dispersion and agglomeration. This research revisits the available models for liquid droplets in solid soft composites and presents a multiscale computational material model to determine their elastic moduli, considering nearly all relevant uncertainties and heterogeneities at different length scales. The effects of surface tension at droplets interface, their volume fraction, size, size polydispersity and agglomeration on elastic modulus, are considered. Different micromechanical material models are incorporated into the presented computational framework. The results clearly indicate both softening and stiffening effects of liquid droplets and show that the model can precisely predict the effective properties of liquid droplets in solid soft composites.

Keywords： liquid in solid     soft composite     computational modeling     multiscale model     heterogeneity    

HTML PDF Collect

Endostatin specifically targets both tumor blood vessels and lymphatic vessels

Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 336-340 doi: 10.1007/s11684-011-0163-5

Abstract: Recently, several studies demonstrated that endostatin also inhibits tumor lymphangiogenesis and lymphatic

Keywords： endostatin     angiogenesis     lymphangiogenesis     nystatin     internalization     tumor    

HTML PDF Collect

Title Author Date Type Operation

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Journal Article

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Journal Article

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Journal Article

Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Journal Article

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Journal Article

Computational modeling of fracture in concrete: A review

Luthfi Muhammad Mauludin, Chahmi Oucif

Journal Article

carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor

Journal Article

Analysis of stress and failure in rock specimens with closed and open flaws on the surface

Journal Article

Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Journal Article

A multiscale material model for heterogeneous liquid droplets in solid soft composites

Journal Article

Endostatin specifically targets both tumor blood vessels and lymphatic vessels

Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo

Journal Article